The Metropolitan Railway (Harrow and Uxbridge Railway) constructed the line between Harrow on the Hill and Uxbridge and commenced services on 4 July 1904 with, initially, Ruislip being the only intermediate stop. At first, services were operated by steam trains, but track electrification was completed in the subsequent months and electric trains began operating on 1 January 1905. Progressive development in the north Middlesex area over the next two decades led to the gradual opening of additional stations along the Uxbridge branch to encourage the growth of new residential areas. Rayners Lane opened as Rayners Lane Halt on 26 May 1906, and was named after a local farmer called Daniel Rayner. On 1 March 1910, an extension of the District line was opened from South Harrow to connect with the Metropolitan Railway at Rayners Lane junction east of the station enabling District line trains to serve stations between Rayners Lane and Uxbridge from that date. On 23 October 1933, District line services were replaced by Piccadilly line trains.
The station is located to the west of the junction of Rayners Lane, Alexandra Avenue and Imperial Drive (A4090). It is in Travelcard Zone 5. Just to the East of the station the Piccadilly and Metropolitan lines tracks join for services to Uxbridge and separate going towards Central London. The station was rebuilt in the early 1930s to a design by Charles Holden and Reginald Uren which features the large cube-shaped brick and glass ticket hall capped with a flat reinforced concrete roof and geometrical forms typical of the new stations built in this period. To the west of the station, there is a reversing siding between the running tracks and, during the day, half of the Piccadilly line service reverses here. Two sidings are located south of the station but these are no longer used: there is no connection with the running lines. The station has payphones, a waiting room, toilets and a car park.
Connections: Metropolitan Line. London Buses routes 398, H9, H10 and H12 serve the station.