The station was opened as Brentford Road on 1 January 1869 by the London and South Western Railway (L&SWR) on a new branch line to Richmond built from the West London Joint Railway starting north of Addison Road station (now Kensington (Olympia)). The line ran through Shepherd's Bush and Hammersmith via a now closed curve and Grove Road station in Hammersmith (also now closed). A short connection was also made from the North & South Western Junction Railway (N&SWJR) line to Brentford meeting the L&SWR line immediately north of the station. This line was served by the North London Railway (NLR). Brentford Road station originally had four platforms; two on the line to Richmond and two serving a loop (the Chiswick Curve) which connected to the line through Kew Bridge station. Between 1 June 1870 and 31 October 1870 the Great Western Railway (GWR) briefly ran services from Paddington to Richmond via Hammersmith & City Railway (now the Hammersmith & City line) tracks to Grove Road then on the L&SWR tracks through Gunnersbury. The station was given its current name in 1871. On 1 June 1877, the District Railway (DR, now the District line) opened a short extension from its terminus at Hammersmith to connect to the L&SWR tracks east of Ravenscourt Park station. The DR then began running trains over the L&SWR tracks to Richmond. On 1 October 1877, the Metropolitan Railway (MR, now the Metropolitan line) restarted the GWR's former service to Richmond via Grove Road station.
On 8 December 1954 the station was damaged by a tornado which ripped off the roof and injured six people. Almost exactly fifty-two years later, another tornado hit London, damaging several properties in the Kensal Rise area on 7 December 2006. In the 1960s the station was redeveloped with just the two platforms it currently possesses. The London Overground and London Underground services share the same tracks. The station is located off Chiswick High Road (A315) and is in Travelcard Zone 3 with a most unprepossessing entrance (down an alley).
Connections: London Overground. London Buses routes 237, 267, 391, 440 and H91 and night route N9 serve the station. The station has a waiting room, bridge and help points.