The area where the station is, is mentioned in the Domesday Book as belonging to the Dean and Chapter of St Paul's Cathedral. In the time of Henry III (1216–1272), a manor house slightly north-west of what is now the corner of Tottenham Court Road and Euston Road belonged to one William de Tottenhall. In about the 15th century, the area was known variously as Totten, Totham, or Totting Hall. After changing hands several times, the manor was leased for 99 years to Queen Elizabeth, when it came popularly to be called Tottenham Court. In the next century, it appears to have become the property of the Fitzroys, who built Fitzroy Square on a part of the manor estate towards the end of the 18th century. The station opened as part of the original Charing Cross, Euston & Hampstead Railway on 22 June 1907 under the name "Euston Road", and this name can still be seen in the Northern line platform tiling. The platforms were built on the outside of the running lines. The station's name changed to "Warren Street" the following year. In 1934, the current station building replaced the original when escalators were installed. The Victoria line platforms opened on 1 December 1968.
As part of introducing automatic ticket gates with the Victoria line, the ability to freely interchange with Euston Square station was withdrawn on 1 March 1969. At the next station northwards, Euston, there is cross-platform interchange between the Northbound Victoria line and Northbound Northern line (Bank branch); and Southbound Victoria line and Southbound Northern line (Bank branch). To facilitate this, the Victoria line tracks had to switch from the standard left-hand running to right-hand, making the cross-platform interchange in reality in opposite directions, as both lines run east-west at this point. Warren Street also has right-hand running due to its proximity to Euston. The Victoria line platforms at King's Cross St. Pancras (the next station on from Euston) also displays this feature for the same reason. Due to the right-hand running on the Victoria line and the Northern line having side platforms, the doors open on the left on all four platforms. The station has toilets, escalators, help points, payphones and wi-fi.
Connections: Northern Line (Charing Cross Branch). London Buses routes 10, 14, 18, 24, 27, 29, 30, 73, 88, 134, 205 and 390 and night routes N5, N20, N29, N73, N205, N253 and N279 serve the station.